20 Buchanan 



represents the third of the live responses to excitation of the intact nerve 

 of the same side, recorded with the first preparation [Exp. 52]. It was the 

 only one of the five in which the reflex effect attained its maximum early. 

 Fig. 11, A and C (see p. 54) represent the first and eighth, respectively, of 

 the sixteen responses to excitation of the nerve of the same side, recorded 

 with the second preparation, and both show, as indeed did all but two 

 out of the sixteen, the late development of the maximal reflex effect. It 

 will be seen (pp. 43 and 45) that in the one of these two preparations 

 the probable cord delay varied between about 26o- and 30o- ; in the other 

 between 24cr and 33o-. 



In the only two other experiments made upon animals with their arms 

 flexed, recovery had so far progressed that the legs were no longer stiff 

 and extended, buccal respiration appeared to be normal, and the heart was 

 beating very fairly. In neither of these were the reflex electrical responses 

 serial, and the cord delay was not longer than is frequently the case in 

 normal frogs. Fig. 7, A (see p. 50) represents the first of six responses 

 from one of these preparations [Exp. 40]. In this and in the second 

 response, but not in the others, the direct effect was double ; the reflex 

 eftect in this response and in some of the others was less strong ; it did not, 

 in this one, reach its maximum at once, although it did so in those in which 

 it was stronger. Fig. 12, A, C, and E (p. 56), represent the first, second, 

 and seventh of the eight responses recorded (by one of the two gastro- 

 cnemius muscles used) with the other preparation in which the arms were 

 flexed [Exp. 56 R], when the sciatic nerve of the same side was excited. 

 The reflex effects, as will be seen, were in the first two very nearly if not 

 quite as strong as the direct eftects ; they attained their maximal strength 

 at once and in all the responses. In four of the later responses they 

 were even stronger than the direct effects owing to the latter having 

 become weaker. One of these is shown in tig. 12, E. 



In experiments made upon animals in which the drug was either just 

 beginning to take effect or had nearly lost its effect, the heart was, as a 

 rule, beating quite normally. Measurements of the records taken in these 

 remaining experiments have led me to the conclusion that if strychnine 

 has any direct influence at all on the length of the delay in the cord 

 in the case of the same-limb reflex, it diminishes rather than increases it. 

 Thus, whereas without strychnine only one preparation (out of eighteen) 

 gave a value so low as 14o- for the fime taken by the impulse to travel 

 from the particular spot on the nerve stimulated, to, and through, the cord 

 and back again, as many as (six out of nineteen) strychnine preparations 

 [Nos. 4, 8, 14, 16, 42, 48] gave as low a value as this, and four of these 

 each gave it more than once or gave a still lower value (shorter by from 

 1(7 to 2cr) in one or more of the responses. 



In three experiments (one of which only [Exp. 14] is included in the six 

 just referred to) records were taken first of the electrical responses of the 

 one gastrocnemius when its nerve was stimulated, before the administration 



