ON THE RESULTS OF HETEROPLASTIC OVARIAN TRANS- 

 PLANTATION AS COMPARED WITH THOSE PRODUCED 

 BY TRANSPLANTATION IN THE SAME INDIVIDUAL. 

 By F. H. A. Marshall and W. A. Jolly.^ (From the Physiology 

 Department, University of Edinburgh.) 



(Received fur jmblication l^dh January 1908.) 



In a paper published in the Transactions of the Royal Society of Edinburgh 

 we recorded the results of a series of experiments on rats in which the 

 ovaries were removed from the normal position and transplanted beneath 

 the skin or on to the peritoneum. In the present paper an account is 

 given of certain further experiments, the results of which, on the whole, 

 confirm and extend our previous conclusions. One of these experiments 

 was upon a monkey, but the remainder were upon rats, the ovaries being 

 transplanted on to the peritoneum or on to the tissue of the kidney. 



In the case of the latter operation the technique adopted was as follows : — 

 The ovaries were removed from the normal position. An incision was 

 made on the external margin of one of the kidneys, either in the same or in 

 another rat. One or both of the ovaries were then placed inside the 

 incision so that they were in direct contact with the highly vascular cut 

 surface of the kidney. The incision in the kidney with its contained ovary 

 was then sewn up with a catgut stitch and the peritoneal cavity closed. 



The following is an account of the separate experiments : — 



(1) The ovaries were removed from the normal position and grafted 

 together on to the peritoneum of the same rat (homoplastic transplantation) 

 in the manner described in our previous paper. Fourteen and a half 

 months afterwards the rat was killed, when the grafted ovaries were found 

 in position. Microscopic sections showed that the ovarian tissue was 

 normal, several corpora lutea being present. The uterus was also normal. 



(2) The ovaries were removed from the normal position and trans- 

 planted on to the peritoneum of the same individual. At the time of the 

 operation the uterus appeared somewhat distended. After thirteen months 

 the rat was killed, when ovarian tissue was found in the position of the 

 graft. Microscopic examination showed, however, that it had undergone 

 partial degeneration. The uterus now appeared normal, both superficiallj^ 

 and liistologicall}^ 



(3) The ovaries were removed from a rat, and one of them was trans- 

 planted into the right kidne}^ of another rat belonging to a different litter. 



1 Carnegie Fellow. 



