188 Physiological Action of Extracts of the Pituitary Body 



the kidney, and some increase in urine How. The blood pressure raising 

 substance is apparently absent, or is in such small amount that its action 

 is entirel}^ masked by the depressor effects of the glandular extract. 

 Extracts of the lobi inferiores and adjacent brain substance produce the 

 well-marked fall of blood pressure and diminution of kidney volume which 

 are characteristic of extracts of the central nervous system. 



In teleosts the pituitary body consists of an anterior lobe proper 

 characterised by the presence in it of deeply-staining granular cells, an 

 intermediate part of smaller clear cells, and a nervous portion. The latter 

 is surrounded and invaded by the cells of the pars intermedia. Extracts 

 of this portion of the pituitary body, pars nervosa and pars intermedia, 

 produce in the cat the typical effects of extracts of the posterior lobe of 

 mammals, viz. rise of blood pressure, dilatation of the kidney, and increase 

 of urine. 



