NOTE ON THE ACTION OF PITUITARY EXTRACTS UPON THE 

 ENUCLEATED FROG'S ■ EYE. By W. Cramer. (From the 

 Physiology Department, Edinburgh University.) 



{Received for -publication bth March 1908.) 



Extracts of the posterior lobe of the pituitary body of the ox produce a 

 distinct dilatation of the pupil of the enucleated frog's eye. 



By using strong extracts made from the desiccated posterior lobe the 

 action on the pupil becomes apparent within an hour or two. The following 

 experiment, in which a solution made from 0*4 g. desiccated pituitary in 

 3 c.c. of Ringer's solution was used, may be taken as an example. The 

 size of the pupil, which in complete contraction is slit-like, was measured 

 by determining the length of the short diameter by means of a pair of 

 compasses. 



The action of a solution of adrenalin (hemisin) 1 : 10000 is more rapid but 

 not so lasting, as will be seen from the following simultaneous experiment. 



