1 to 8 or 9 per cent. Lee's investigation {Jour- 

 nal of Physiology, 1908, p. 335) found that 

 about half of the total nicotine was present in 

 the smoke according to Lee the pyridin seemed 

 to be entirely without influence. 



Lehmann (Archiv fur Hygiene, 1909, p. 319) 

 found that from 80 to 90% of the total nicotine 

 in a cigar or cigarette was to be found in the 

 smoke. He found also that in the case of cigars 

 about 10 to 18% of the nicotine in the smoke 

 is absorbed by the smoker and that cigarette 

 smoke absorbed by the smoker contains a less 

 proportion of the nicotine in the tobacco than 

 is the case with cigars. The general opinion 

 is, however, that about one-seventh of the nico- 

 tine in the tobacco will be found in the smoke. 



Entirely at variance with these results are 

 those obtained recently by A. D. Bush, M.D., 

 Instructor of Physiology in the University of 

 Vermont (New York Medical Journal, March 

 14, 1914), and those obtained in the laboratory 

 investigation by the London Laucet. Bush 

 made long and extensive investigations on the 

 effects of tobacco smoking and criticised the 

 results of previous workers. He shows very 

 clearly that in many cases the conclusions 

 drawn by them as regards nicotine contained in 

 tobacco smoke are either entirely erroneous or 

 that the deductions made from the investiga- 



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