164 RABIES. 



I presented to the committee nineteen vaccinated dogs, all of whom had 

 been rendered insusceptible by preventive inoculation, and thirteen of 

 these had been further tested after vaccination by inoculation by trephin- 

 ing. 



These nineteen dogs were compared in various ways with nineteen other 

 dogs chosen for the purpose of experiments. On June 1st. two of the pro- 

 tected dogs and two trial dogs were inoculated by trephining under the 

 dura mater with the bulb of a mad dog. On June 3d. one protected dog 

 and one trial dog were bitten by a mad dog. On June 4th. the same mad 

 dog bit another protected and another trial dog. June Gth. the mad dog 

 used June 3d. and 4th. died, and the bulb was inoculated by trephining on 

 three trial and three protected dogs. 



June 10th. one protected and one trial dog were bitten by another mad 

 dog obtained from the streets; June 16th. one protected and one trial dog 

 were bitten by a dog which had gone mad June 14th. as a result of the ex- 

 periments; June 19th. three protected and three trial dogs inoculated in 

 popliteal veins with bulb of mad dog; June 20th. six protected and four 

 trial dogs inoculated in vein; June 2Sth. two protected and two trial dogs 

 bitten by mad dog at the hospital of M. Paul Simon, a veterinary surgeon. 



Now let us look at the results. — The Com. performed experiments on 

 thirty-eight dogs, nineteen protected and nineteen not protected. They 

 report that in the case of the nineteen trial dogs, rabies occurred as fol- 

 lows : — of six bitten, rabies occurred in three; of seven inoculated in 

 vein, rabies in five; of five trephined, all died. Trephining was the surest. 

 On the other hand, not a single symptom of rabies appeared in any of the 

 dogs vaccinated by me and declared insusceptible; one dog died from 

 diarrhoea, the cause of death being verified by post-mortem and also by 

 tests. Three rabbits and one guinea pig were inoculated with the bulb 

 of this dog and are in the best of health. The animals are still under 

 observation." 



The following is a literally translated extract from the address of M. 

 Bouley, before the French Association for Advancement of Sciences.— 



Living nature of the contagion and Inoculation preventive of 

 tHE Hydrophobia. 



" Nothing is conjectural now. The agent of the contagion is a living 

 agent, already known for an important group of contagious diseases. This 

 agent, this living element, we have been able to master, to observe it in 

 the midst of artificials proper for its culture ; we have been able to study 

 its physiology, modes of existence; we have been able to subject it to 

 profound modifying influences; to create, so to speak, races in different 

 species. In short we have been able to see it by our own work in the 

 living organisms, in conditions vigorously determined by the experimen- 



