MALARIA Sy 



The bone-marrow is hypercemic and chocolate-brown in colour. 



The brain is normal, or in the cerebral type of the disease one finds 

 oedema, hyper^emia of leptomeninges; broM'n or black pigmenta- 

 tion of cortex and punctiform haemorrhages in the white matter under 

 the cortex. 



The spinal canal is similar to the brain. 



The retina may show numerous haemorrhages. 



Microscopic. 



Parasites are found in the blood of the heart, spleen, bone-marrow, 

 capillaries of brain, intestine, pancreas, &c., but the types are not 

 differentiated clearly after death. They shrink considerably. The 

 mononuclears show pigment granules. The polys show phagocytosis 

 in a small degree. Macrophages rnay be seen from the internal organs 

 containing parasites and red cells. 



The heart muscle is loaded with hasmosiderin and the capillaries 

 with parasites. 



The lungs contain parasites in all stages of development with pig- 

 mented macrophages and leucocytes. The pneumococcus is always 

 present, and perhaps forms a double infection. 



The capillaries of the liver are enlarged and swollen by the endo- 

 thelial cells loaded with pigment, and filled with blood cells containing 

 parasites and leucocytes with pigment. 



The perivascular h-mphatics are swollen. 



The liver cells are compressed between dilated capillaries and 

 contain hasmosiderin ar.:l bile pigment. Rarelv there are localized 

 patches of necrosis. 



The portal canals are infiltrated with red cells containing parasites. 



The red cells of the spleen show schizonts and crescents. 



The leucocytes and macrophages show pigment. 



The kidneys show pigmentation of the capillarv walls of the 

 glomeruli. Parasites are rare here, but plentiful between the tubules. 

 Phagocytes with pigment and parasites are not uncommonlv seen here. 

 The cells of the glomeruli degenerate and are cast off into the capsule; 

 the epithelial cells of the convoluted tubules degenerate and are cast 

 off into the lumen. 



The suprarenals show irregular areas of vasodilatation, full of red 

 cells, many of which contain parasites. 



The same may be said of the capillaries of the abdominal fat. 



The bone-marrow is chocolate-coloured in the small bones and 

 brownish red in the long ones. It is soft, diffluent, contains sporu- 

 lating parasites and crescents. 



The brain in cerebral cases has the capillaries full of sporulating 

 parasites, mononuclear elements, macrophages containing dead para- 



