17 



(fig. 11), It seems posaitle that a siiia.ll aj/iount of cliro- 

 matin is distributed on the peripheral linin net.vork, but 

 the "bulk of it is certainly in the nucleolus. As the nucle- 

 us prepares for mitosis, it increases somev/hat in size, "be- 

 coming about 4,5 1^ in diameter; the nucleolus also enlarges, 

 ehroiiiatin from the nucleolus, in the form of rather large 

 granules, passes out to the periphery of the nucleus along 

 faint linin strands (figs, 14, 15), very much as v/as de- 

 scribed \)y V/olfe in Nemalion (»04), At the same time, the 

 nucleolus becomes differentiated into faintly and darkly 

 staining areas, the latter probably representing cioroi-ie-tin. 

 The cliromatin continues to pass out of the nucleolus until 

 the whole cliroma,tin content is distributed throiigh the nu- 

 clear cavity in the form of granules, some of which are 

 connected with each other by linin tiireads (figs. 16,17,13, 

 19,20) . The nui.iber of these granules seems in every case 

 examined to be more thy.n tv/ice the niuaber of chromosomes 

 and in some insta^nces the graniiles bedome much more numer- 

 ous (fig. 17). The granules now a-pproach the centre of the 

 nucleus, at the saiae time becoming fev/er in number, prob- 

 ably b^"" the fusion of separate granules, (fig, 21). As 

 they move tov/cj?d the centre, they become arranged roughly 

 in a flat plate, t}iougli al i. the granules do not lie in ex- 

 actly one plane (fig. 2,1 ). VHiile this is going on, a 



