66 



THE VENOMS OF CERTAIN T H A N A T P HI D E M. 



Experiment No. 26. 



Time : Pulsations REMARKS, 



min. sec. per minute. 



Normal . . . 320 Pneumogastric nerves cut. Injected intravenously 0.006 



10 sift grain dried Cobra venom prepared as iu the foregoing 



30 330 experiment. 



1 00 330 



1 30 330 



3 30 335 



5 30 340 



9 30 320 



11 30 330 



18 30 ... Convulsions; asphyxia; death in 2^ minutes. 



Experiment No. 27. 



Time : Pulsations 



min. sec. per minute. 



REMARKS. 



Normal 





 10 

 20 



1 00 



2 00 

 4 00 



10 

 15 



390 



396 

 390 

 360 

 354 



Pneumogastric nerves cut. Injected intravenously 0.003 

 gram dried Cobra veuoiu dissolved in 1 c. c. distilled water. 



Clot in canula. 

 Dead of asphyxia. 



The Actions of Pure Venoms on Animals in which Sections of the Pneitmor/astric 

 Nerves and of the Upper Cervical Portion of the Spinal Cord had been made. 

 After isolation of the heart from the nerve centres by making section of the 

 pneumogastric nerves and spinal cord in the middle or upper cervical region, and 

 maintaining the animal alive by means of artificial respiration, we find that the 

 pulsations of the heart are almost invariably slightly diminished in frequency 

 upon use of venom. Seven experiments were made: three with the venom of the 

 Crotalus adamanteus ; one with the Crotalus horridus ; one with the Ancistrodon 

 piscivorus ; one with the Ancistrodon contortrix, and one with Cobra. In one expe- 

 riment with the Crotahts adamanteus in which two doses were given, there occurred 

 a diminution after the first dose, while there was a marked increase after the second. 

 In the experiment with the Crotalus horridus there was but little alteration. 



Experiment No. 28. 



Normal 



REMARKS. 



Pneumogastric nerves and cord cut. Injected intravenously 

 0.003 gram dried venom of the Crotalus adamanteus dis- 

 solved in 1 c. c. distilled water. 



Dead. 



