78 



THE VENOMS OF CERTAIN THANATOPHIDE^E. 



Experiment No. 53. 



Normal 



REMARKS. 



Pneuinogastric nerves and cord cut. Injected intravenously 

 0.0017 gram dialysis-venom-globulin from the dried venom 

 of the Crolalus adamanleus. 



Injected 0.0034 gram. 



18 00 



Experiment No. 54. 



Normal 



Time: 

 min. sec. 



10 



20 

 30 

 40 

 50 

 00 

 10 

 20 

 00 



Pulsations 



per minute. 



300 



290 

 290 

 300 

 300 

 300 

 300 

 300 

 300 



Dead. 



REMARKS 



Pneumogastrie nerves and cord cut. Injected intravenously 

 0.0068 gram dialysis-venom-globulin from the dried venom 

 of the Crotalus adamanleus. 



Tremors. 



Clot formed in canula. 

 Dead. 



A review of the results of these experiments with the globulins on the pulse-rate 

 in normal animals indicates that water-venom-globulin is the most potent, and the 

 copper-venom-globulin the least so. With the former there occurred in four of the 

 six experiments a primary increase followed by a fall, while in the other two there 

 was a diminution from the first. In experiments with the copper-venom-globuliu 

 and dialysis-venom-globulin there was always a primary increase, and in four out of 

 the five experiments this was followed by a decline. 



After section of the pneumogastric nerves a primary increase (due probably to 

 some accidental cause) occurred in one out of the five experiments, in two of 

 the other four there at first was no appreciable change, and then a diminu- 

 tion, while in the remaining two there was a lessening of the rate from the 

 time of injection. These results suggest that the increase of the pulse-rate, which 

 occurred in animals with intact vagi, was in some degree at least dependent upon 

 an influence exerted through the pneumogastric centres and nerves. It will be 

 observed that we here have results which are directly opposed to what we have 

 seen with pure venom ; that is a lessened tendency to the primary increase of the 



