BROWN-S&QUARUS EXPERIMENTS 231 



(2) " Epileptic " symptoms appeared in the offspring of parents 



who had been rendered " epileptic " by section of the 

 sciatic nerve. 



(3) An abnormal change in the shape of the ear was observed in 



the offspring of parents in which a similar change followed 

 a division of the cervical sympathetic nerve. 



(4) Partial closure of the eyelids was observed in the offspring of 



parents in which that state of the eyelids had resulted 

 either from section of the cervical sympathetic nerve, 

 or the removal of the superior cervical ganglion. 



(5) An injury to the restiform body (associated with the medulla 



oblongata) was followed by a protrusion of the eye 

 (exophthalmia), and this reappeared in the offspring some- 

 times through four generations, even affecting both sides, 

 though the lesion in the parent had only been on one 

 of the corpora restiformia. 



(6) An injury to the restiform body near the nib of the calamus 



was followed by hsematoma and dry gangrene of the 

 ears, and the same conditions reappeared in the 

 offspring. 



(7) After a section of the sciatic nerve, or of the sciatic and crural, 



some of the guinea-pigs gnawed off two or three of the 

 toes, which had become anaesthetic ; in the offspring two 

 or three toes were absent. Sometimes, instead of complete 

 absence of the toes, only a part of one or two or three was 

 missing in the young, although in the parent there was a 

 loss not only of the toes, but of the whole foot (partly eaten 

 off, partly destroyed by inflammation, ulceration, or 

 gangrene). 



(8) As effects of an injury to the sciatic nerve, there followed 



various morbid states of the skin and hair of the neck and 

 the face, and similar alterations in the same parts were 

 observed in the offspring. 



When the sciatic nerve had been cut in the parent, the descend- 

 ants sometimes showed a morbid state of the nerve. There was 

 also a similarity in the successive appearance of the phenomena, 

 described by Brown-Sequard as characteristic of the periods of 

 development and of abatement of the " epilepsy," especially in 

 the appearance of the epileptogenic area and the disappearance of 

 hair around that area whenever the disease showed itself. 



