34 



THE SEX-COMPLEX 



Diminution 



oophorec- 



Growth of 



o5phorec- er 

 tomy. 



same number of days before and after operation. 

 Further, of the two bitches, weighing 13 Ib. and 16 Ib. 

 respectively, the former excreted a total of 0-529 gramme 

 of CaO in 20 days before operation, and 0-532 gramme 

 in the same period after operation a very slight increase ; 

 while the latter excreted 6 '745 grammes of CaO in 20 

 days before operation, and only 1-869 grammes in the 

 same time after operation. Surely these are extra- 

 ordinary figures on which to base the conclusions at 

 which this investigator arrived ; for the last animal 

 excreted before operation about three and a half times 

 as much CaO as she did afterwards, and the first an 

 infinitesimal amount more after operation than before. 

 This is confirmatory of my figures, and diametrically 

 opposed to McCrudden's own statements. 



Louise Mcllroy 1 , working with a somewhat similar 

 method on one animal only, also states that the output 

 of calcium is increased after oophorectomy. Her work 

 was carried out to confirm that of McCrudden ; and she 

 gives no figures to enable us to check her conclusions. 



Curatulo and Tarulli 2 , also Neumann and Vas 3 , 

 found a reduction in the excretion of calcium and phos- 

 phorus after administering ovarian substance. Luthje 4 

 could find no change in the metabolism after adminis- 

 tration. Heymann, quoted by Biedl 6 , found reduction 

 in the phosphorus content of the bones of rats after 

 oophorectomy. 



In young animals there is almost always an increase 

 above the normal in the growth of the long bones after 

 oophorectomy, due to delay in the ossification of the 

 epiphysial cartilages. 



It may be of interest to call attention to a few other 



1 Mcllroy, Louise, Proc. Roy. Soc. Med., 1912, vol. v, p. 369, 

 8 Curatulo, G. E., and L. Tarulli, CentralW.f. Gyndk., 1895, vol.xiv, 

 p. 555. 



3 Neumann, S., and B. Vas, Monatsch. /. Gel. u. Gyndk., 1902, 

 vol. xv, p. 433. 



4 Luthje 1 , H., Archiv. f. Exper. Pathol u. PharmakoL, 1902, vol. 

 xlviii, p. 184 ; 1903, vol. 1, p. 268. 



6 Biedl, A., Innere Sekretion, 1913, 2nd ed. 



