144 THE SEX-COMPLEX 



Histoiogical The masses and columns of cells, which do not form 

 author's case tubules, resemble what may be seen in the early stage 

 of glandular m the development of the normal testis : they have none 



partial . . 



herm- of the appearances of malignant cells, for their nuclei are 



3m ' regular and quiescent, and the cells themselves are nearly 

 all of one size and appear stable in their mode of growth. 

 With regard to the interstitial cells it might be 

 thought that they were ovarian and not testicular. As 

 a rule, however, the interstitial cells of the ovary are 

 much smaller, and never have I seen them so well 

 marked, either in normal or pathological circumstances, 

 as here shown. Further, if these interstitial cells were 

 really ovarian one would expect to find them in the 

 ovarian portion of the ovitestis from which they are 

 entirely absent rather than in the testicular portion. 



This is the general picture presented by an ovi- 

 testis ; but in the histological diagnosis of the condition 

 there must always be difficulty. In the first place, there 

 are masses of columnar cells which have no definite 

 tubular arrangement. It was probably this irregularity 

 of distribution which gave rise to the opinion, to which 

 allusion has already been made, that in the case 

 described the growth was malignant. In some parts, of 

 course, there is a definitely tubular arrangement of the 

 darkly staining columnar cells ; and in other places 

 tubules may be found lined with a single layer of 

 epithelium, and containing secretion. There is, however, 

 never any definite spermatogenesis to be seen. 

 Clinial It is particularly interesting to note in regard to the 



au?hor'scase case recor ded above, that the patient commenced life 

 of glandular and passed puberty as a normal girl, menstruating 

 herm- regularly for eighteen months ; that menstruation had 



aphroditism. tnen cease( j an( j masculine characteristics had developed, 

 and that in spite of this she suffered with slight meno- 

 pausal symptoms after operation, and has now reverted 

 entirely to the feminine or to a neutral type. This, 

 surely, is dual sex-characterization,if ever there were such 

 a thing : an interesting question which we shall discuss 

 more fully after considering the other varieties of 



