CONTENTS vii 



SECTION 



5. Trimethyl-histidine . . 45 



6. Ergothioneine (Thiolhistidine Betaine) - - - - 46 



7. Hypaphorine (Trimethyl-tryptophane) - - - 47 



8. Trigonelline (Methylnicotinic Acid) - . . 47 



9. Other Pyridine Bases - - - - 48 



10. y-n-Butyrobetaine - 49 



11. Carnitine (Novaine, a-Hydroxy-y-butyrobetaine) - - - 50 



12. Myokynine - 52 



CHAPTER IV. 



CHOLINE AND ALLIED SUBSTANCES - - - - - 53 



SECTION 



1. Choline- . 54 



2. Ammo-ethyl Alcohol (Colamine) and the Origin of Choline ; 



the possible Presence of other Bases in Phosphatides 58 



3. Neurine- 60 



4. Physiological Action of Choline and of Neurine - - 61 



5. Natural and Synthetic Muscarines and their Physiological 



Action 64 



6. Trimethylamine Oxide - -67 



7. Neosine- ......... 55 



CHAPTER V. 



CREATINE, CREATININE, GLYCOCYAMINE AND GUANIDINES - - 69 



SECTION 



1. Creatine and Creatinine - - 69 



2. Physiology of Creatine and Creatinine - 71 



a. Distribution - 71 



b. Metabolism - - - 73 



c. Possible Precursors of Creatine - .77 



3. Glycocyamine and Glycocyamidine - - 78 



4. Guanidine - - 79 



5. Methylguanidine - - 79 



6. as-Dimethylguanidine - 80 



CHAPTER VI. 



ADRENALINE - 81 



SECTION 



1. Historical - 81 



2. Nomenclature and Synonyms - 83 



3. Preparation and Purification of Natural Adrenaline - 84 



4. Syntheses of Adrenaline - 85 



5. Adrenaline Substitutes - 87 



6. Physical and Chemical Properties of Adrenaline. Salts and 



Derivatives. Constitution - 87 



7. Colour Reactions of Adrenaline and Colorimetric Estimation 89 



8. Amount of Adrenaline in the Suprarenal Gland ; Yield ; 



Distribution in other Organs ; Origin - 92 



