GLANDERS 323 



septum. Similar nodules may be found in the lungs, and 

 less often in the liver and kidneys. 



In ^landers of the skin, or farcy, nodules are found in 

 the skin and the imderlyini: tissues. These nodules are 

 usually called farcy buds. They vary in size from a hemp- 

 seed to that of an err. These nodules break and form run- 

 ning sores on the surface of the body, the discharge being 

 yellow and sticky. The sores thus formed often heal and 

 leave marked seal's on the head and legs, in which places 

 they are most common. 



The acute form of the disease is common in the mule and 

 ass, but is rare in the horse. Death often takes place in 

 from two to four weeks, although the disease may become 

 chronic and the animal live for a number of years. Treat- 

 ment is of little avail. Great precaution should be exer- 

 cised in the care of glandered animals, since if any of the 

 infections material is introduced into the eyes or nose, or 

 comes in contact with a wound, infection of the human 

 being is likely to occur. The manifestations of glanders in 

 man are quite similar to those noted in the case of the horse. 



Detection. Glanders is often easily recognized by the 

 characteristic lesions in the nasal passages or by the farcy 

 buds. When the disease can not be recognized by physical 

 examination, recourse must be had to some other method of 

 diagnosis. The most common method is to apply the 

 mallein test, which is very similar to the tuberculin test in 

 the nature and manner of application. Mallein is pre- 

 pared by in'owinu the glanders organism in glycerin broth. 

 The culture is then killed by heating, and the dead cells re- 

 moved by filtration. The mallein is injected beneath the 

 skin, and a series of temperature readings is made both be- 

 fore and after the application of the mallein. 



A few hours a tier the introduction of the mallein there 

 appears at the point of injection a swelling which, in the 



