AUXETIC IN CANCER PLASMA 293 



number of chromosome granules. But this digression 

 from the main researches also taught us that other 

 facts were to be learnt from the comparison of samples 

 of peripheral blood from twenty- two cancer patients 

 and forty-seven " others." Never before had systematic 

 examination of blood from such groups of persons been 

 made by the in-vitro staining of their cells, and it was 

 soon noticed that in the samples of cancer blood the 

 actual number of eosinophile leucocytes was reduced; 

 in fact, four cases could hot be included in our category, 

 because, even after repeated examination of many 

 samples of their blood, no eosinophile leucocytes could 

 be found; and in all the other cases, with the exception 

 of three, there was an undoubted reduction in the 

 number of eosinophile cells. In the three exceptions 

 there appeared to be an eosinophilia. 



In some cases of carcinoma, also, there was a large- 

 lymphocytosis, especially in the advanced cases. But 

 this is by no means an absolute rule, and, moreover, a 

 large-lymphocytosis was fairly common among the 

 control specimens. 



But a still more important point was observed. 

 We have already shown how a mixture of azur dye 

 and atropine causes excitation of amoeboid movements 

 in leucocytes and lymphocytes, then the discard of 

 granules (flagellation), and lastly augmented cell- 

 division; also that an agent has been detected in 

 the plasma of carcinoma patients which induces the 

 first two i.e. excitation of amoeboid movements 

 and the discard of granules. We have just shown 

 that the granules in certain leucocytes in cancer 



