346 THE CHEMISTRY OF PROLIFERATION 



in an ulcer, an increased number of deaths is occasioned, 

 which in its turn still further increases the proliferation, 

 as seen in the ulcers once treated with globin. 



The application of dry globin to a scarified sore has 

 elicited the interesting fact that it will convert the dark 

 venous blood drawn by the scarification into the bright 

 and red arterial variety, and the scars resulting from 

 the treatment appear to be exceptionally firm and un- 

 likely to break down again. 



This form of treatment, however, must be carried 

 out with care, and suppuration not allowed to continue 

 for long in the presence of an auxetic, for, as will be 

 shown in the next chapter, there is a possibility of 

 malignant proliferation occurring in place of the normal 

 one if the products of decomposition become pent up 

 in the neighbourhood of proliferating epithelial cells. 



These experiments afford conclusive proof that the 

 cell-proliferation of healing can be caused by the chem- 

 ical auxetics, kreatin and globin, and that the deduc- 

 tions made from the prolonged experimentations with 

 the in-vitro method described in this book are correct. 

 The possibility of the mitotic divisions induced on the 

 microscope slide being in the nature of "freaks" or 

 being due to death-struggles is disproved. As a matter 

 of fact, these possibilities practically fell to the ground 

 when mitoses were induced by extracts of dead tissues. 

 One could conceive that a purely artificial substance 

 like azur dye might cause mitosis by exciting the cells 

 greatly just before death; but we think that in all 

 probability the aniline dye contains some constituent 



