METASTASIS 367 



The possibility of carcinoma being due to the 

 combination of alkaloids and auxetics will also 

 explain the reason for the way in which malignant 

 growths frequently "break down." As shown by 

 in-vitro experimentation, cells can only withstand a 

 certain quantity of the combination. If excess is 

 forced into them, they will die. Even globin itself 

 is very poisonous to leucocytes and lymphocytes if it 

 is in excess. If this excess was present in the body, 

 it would cause cell-death unless the excess was 

 removed, and the cell-death would only aggravate 

 the trouble, especially if the lymphatics were blocked 

 by malignant cells. Ultimately, of course, the growth 

 would "point" and break down. A certain amount 

 of local cell-death will cause increased cell-proliferation ; 

 but after a certain stage is reached, breaking down must 

 occur with subsequent ulceration. 



Up to a certain point, therefore, the greater the 

 malignant proliferation, the more cell-death will there 

 be, and the more will the disease be aggravated. 

 And the aggravation may be increased by the 

 chromosome granules which cells appear to discard 

 when they are excessively prolific. These chromatin 

 granules may contain kreatin, and they will therefore 

 merely supply more auxetic for the neighbouring 

 cells. 



The phenomenon of metastasis in cancer is an im- 

 portant factor to be considered in conjunction with the 

 other facts. The invasion of lymphatics by cancer may 

 be due to the combination of auxetics and alkaloid 

 being passed through them from the original healing 



