384 PREVENTION OF PROLIFERATION 



amelioration of symptoms by general treatment, one 

 might also be able to improve an accessible growth by 

 locally inducing the proliferation of healing in it. If 

 this were possible, and if a local, inoperable, broken- 

 down scirrhus could be so improved by local treatment as 

 to replace some of the infiltrating cells by normal ones, 

 I considered that I should be justified then in carry- 

 ing out the crucial test on these normal cells, and try to 

 reinduce the abnormal infiltration amongst them once 

 more by the direct application of auxetics and choline. 

 In other words, if a case already has a large "inopera- 

 ble" tumor and one is able to convert by treatment a 

 portion of it into normal tissue, it would be useful to try 

 temporarily to reconvert the normal tissue back into 

 original condition in order to prove the main point of 

 our researches. There would already be a neoplasm, 

 and I proposed thus to test our theory in in vivo on a 

 portion of it. 



A patient suffered from an inoperable, fungating 

 seirrhus of the breast. The ulcerated surface was about 

 four inches in diameter. The edges were precipitous 

 and excavated, and the whole appearance of the ulcer 

 was typical of carcinoma. The surface was practically 

 devoid of granulation tissue, and sections of it clearly 

 showed its nature (figs. 119, 120). A portion of the sur- 

 face, i.e. about a third of it, was scarified and globin 

 was applied by being "dotted" over it (fig. 121). The 

 remaining part of the ulcerated surface \vas untreated. 

 No dressings were applied. This ulcer had a remarka- 

 ble propensity for suppurating. No matter what was 



