LOCAL EFFECTS OF GLOBIN 389 



done to try to keep it "clean," pus quickly formed on 

 its surface much more quickly than it did on the be- 

 nign callous ulcers which were also being treated. The 

 result was that the scab formed by the globin very 

 quickly broke down. When this occurred, the scab was 

 removed by fomentations and the ulcer cleaned up as 

 much as possible. Then the globin treatment was re- 

 peated, but it was always applied to the same portion 

 of the ulcer. The other portion never received an ap- 

 plication. This was repeated many times. 



The improvement in the treated portion was gradual, 

 but it was marked. The precipitous edges appeared 

 to soften and become flattened. The base no longer 

 suppurated in a few hours, and the suppuration was 

 practically confined to the untreated portion. The 

 glistening malignant surface of the treated portion 

 gradually gave place to granulation tissue, and after 

 about a fortnight's treatment there was a contrast be- 

 tween the treated and untreated portions of the broken- 

 down surface. A portion of the treated part of the 

 ulcer was now removed and sections cut from it, which 

 show that the abnormal cells were now giving place to 

 normal granulation tissue, 



The treatment was continued once more, two parts 

 of kreatin now being added to five parts of globin, 

 and soon it was seen that the treated portion became 

 softer, and the ulcerated edge ceased to extend. 

 Another section was then cut, which showed that 

 that part of the ulcer now seemed to be devoid of 

 abnormal infiltration (figs. 122, 123). 



