ATTEMPTED CRUCIAL TEST 395 



but from the general appearance of the ulcer, 

 as well as from the microscopical section of it, we 

 certainly think that it was the mixture of globin 

 and choline which caused the reinfiltration. The 

 application of globin alone to the edges of the 

 sore merely induced the appearance of granulation 

 tissue, and one would think that if a mixture of 

 globin and choline does not cause carcinoma, it 

 would merely have produced augmented proliferation 

 of the healing cells w r ith more granulation tissue; 

 but apparently a new infiltration of epithelial cells 

 appeared. I hope to be able to repeat this test 

 under more favourable conditions. 



The whole ulcer is now being treated with a 

 mixture of globin and kreatin, and, although the 

 edges of it are extending in some places, there can 

 be no doubt that, on the surface at least, malignant 

 cells are being replaced by normal granulation tissue. 

 The whole growth is now comparatively freely mov- 

 able, and it does not discharge profusely as it did. 

 The patient no longer complains of pain, and, except 

 for the extending edges, her general condition has 

 greatly improved. 



As it is possible that carcinoma may be due to 

 the causes described in this book, and since the 

 general treatment by defibrinated blood per rectum 

 and the local treatment by globin and kreatin seem 

 to have been followed by improvement, we think 

 that the former might be tried to prevent recurrence 

 after removal of a growth. Unfortunately we are 

 not in a position to try this experiment, as early 



