414 APPENDIX II 



Leucocytes from cases of phthisis; plasma from other cases of 

 phthisis. Four experiments. 50 per cent dead was the average 

 in 18 hours; very little difference from controls, sometimes the 

 cells lived longer than in the controls. 



Leucocytes from cases of malaria; plasma from cases of typhoid 

 fever. The majority of the cells in most instances were dead in 

 14 hours. Differences varied from four to six hours. 



Leucocytes from cases of typhoid fever; plasma from cases of 

 malaria. About 50 per cent were usually dead in 16 hours and 

 all were dead in 20 hours in all cases. Five cases tried; average 

 difference about three hours. 



Healthy person's leucocytes; plasma from cases of carcinoma. 

 Seven cases; all cells alive in 16 hours; a large number alive in 20 

 hours. Usually there was little difference between the effect of 

 cancer plasma and that of a healthy person. 



From the foregoing measurements it would appear that in the 

 cases which have been experimented Avith the plasma of persons 

 suffering from infective diseases is poisonous to a healthy person's 

 leucocytes and to the leucocytes of another person suffering from 

 another disease, but is not so poisonous to the leucocytes of another 

 person suffering from the same disease. I submit that it may be 

 reasonable to suppose that such may be the case in other infective 

 diseases. 



Precautions.- In comparing the lengths of the lives of leucocytes 

 of persons suffering from chronic infective diseases both in another 

 infected person's plasma and in healthy plasma, I have frequently 

 found that such cells will not live so long as the cells of healthy 

 persons subjected to the same conditions. This was further inves- 

 tigated by comparing the lives of leucocytes taken from cases of 

 chronic illnesses in their own plasmata with the length of the lives 

 of the cells of healthy persons in their own healthy plasmata. In 

 cases of chronic phthisis, malaria, Hodgkin's disease, 1 etc., I have 

 found that the leucocytes will not live even in their own plasma 

 nearly so long as if they belonged to a healthy person, as much as 



1 It has been noticed that stain will diffuse more readily into the blood- 

 cells of these patients that is, that these diseases, and probably other 

 chronic illnesses, cause a lowered "coefficient of diffusion" in blood-cor- 

 puscles. 



