340 THE ADRENAL, GENERAL MOTOR, AND VAGAL SYSTEMS. 



inferred, says Professor Schafer, "that the injection has passed 

 directly from the blood-vessels into the liver-cells; indeed, here 

 and there one can see what appear to be such direct commu- 

 nications." These can readily be seen in the annexed illustra- 

 tion. He refers to the conclusion reached by Browicz, 17 based 

 on appearances, normal and pathological, "that there must 

 exist a net-work of nutritive canals, within the hepatic cells 

 which are in direct communication with lobular capillaries"; 

 this he had not as yet, however, verified by injections. 

 Schafer' s observation probably accounts for the direct transfer 

 of the bilirubin to the biliary capillaries, along with other 



LIVER OF RABBIT INJECTED FROM THE PORTAL VEIN. THE 

 INJECTION HAS PASSED INTO CANALICULI WITHIN THE LIVER- 

 CELLS. (E. A. Schafer.) 



products of oxidation, to which we will refer later on. Indeed, 

 J. W. and E. H. Fraser 18 are also stated to have found intra- 

 cellular passages communicating with the blood-vessels in the 

 hepatic cells of frogs. For the present it seems logical to con- 

 clude that one or more of the canaliculi may lead to the vacuole 

 previously referred to as nearest the bile-capillaries, and that 

 it is in this vacuole that bilirubin joins the bile. That even 

 this vacuole is supplied with a canaliculus we have already 



"Browicz: Bulletin de 1'Acadgmie des Sciences de Cracovie, 1899. 

 J. W. and E. H. Fraser: Journal of Anatomy and Physiology, vol. xxlx. 

 p. 240, 1895. 



