380 INTERNAL SECRETIONS OF PANCREAS AND SPLEEN. 



minutes afterward the remaining half of the pancreas of the 

 latter dog was infused exactly like the first; of the two in- 

 fusions when given fibrin and albumin, the second- only digested 

 rapidly and copiously." 



The investigations of Popelski are next reviewed. "In 

 both normal and splenectomized cats/' says Bellamy, "he col- 

 lected the pancreatic juice by means of a cannula introduced 

 into the duct of the gland, and was unable to find any differ- 

 ence in digestive activity. As, however, his cats had been 

 fasting since the day before, his experiments were made out- 

 side the digestive period during which the spleen, becoming 

 congested, furnishes abundantly its product of internal secre- 

 tion which transforms rapidly and copiously the zymogen into 

 trypsin." . . . "But Popelski also performed some anal- 

 ogous experiments on a dog with a permanent pancreatic fist- 

 ula, made according to the method of Pawloff. The pancreatic 

 juice of this animal was several times collected and examined 

 before and after splenectomy without any difference in activity 

 being demonstrable. This result, however, elicits no surprise 

 in view of the fact that in both instances the juice was always 

 collected immediately after a meal i.e., again to repeat it 

 in advance of that digestive period during which the spleen 

 enters into function and the pancreas abounds in trypsin; so 

 that as well in this experiment as in that with his cats, Popelski 

 was placed in that position in which the presence or absence 

 of the spleen was a matter of perfect indifference. . . ." 

 The discussion of the various features in point have led to 

 considerable acrimony, but the impartial observer cannot fail 

 to consider that the position of Herzen, of those reviewed, is 

 the only tenable one. 



In an article written since Bellamy's review was published 

 Popelski 11 reiterates his views, and states that since it has 

 been demonstrated that there exist in the organism bodies in 

 the nature of ferments possessing oxidizing properties, which he 

 believes to be derived mainly from leucocytes, the results 

 obtained by Schiff, Herzen, Pachon and Gachet can all be 

 explained by their action. During the height of digestion 



n Popelski: Vratch, Feb. 3, 1901. 



