412 INTERNAL SECRETIONS OF PANCREAS AND SPLEEN. 



glycosuria, it will become apparent that these two factors ac- 

 count for the phenomena observed in many cases: calculi, 

 lipomatosis, hypertrophy, tumors, induration, and periglandular 

 sclerosis. Atrophy, a condition which in itself implies func- 

 tional impairment, on the other hand, constitutes the major- 

 ity of the remaining pathological processes encountered post- 

 mortem in this organ. 



But the question which now imposes itself is this: Why 

 and how does a condition that interferes with the conversion 

 of trypsinogen into trypsin or that impedes the passage of the 

 latter to the intestinal foodstuffs cause diabetes? The answer 

 now seems plain, viz.: because insufficiency of trypsin is fol- 

 lowed by imperfect reduction of proteids to simpler bodies, result- 

 ing in the formation or inadequate splitting of toxic albuminoids. 

 In other words, impaired pancreatic action of the kind men- 

 tioned gives rise to toxic glycosuria. 



Our interpretation of the general subject seems again to 

 conciliate antagonistic views. Indeed, while Lepine 29 has 

 affirmed that "the pancreas exercised a glycolytic influence," 

 Chauveau and Kaufmann have held the opposite: i.e., that 

 "glycolysis is not diminished in diabetes, and that diabetes is 

 exclusively due to an increase in the production of glucose." 

 We have shown that the arterial blood of the pancreas does 

 contain a glycolytic body, the oxidizing substance, but we 

 have also by our analysis of Cartier's paper and other data 

 demonstrated that suprarenal overactivity was the underlying 

 cause of toxic glycosuria: i.e., & source of increased production 

 of sugar. To further sustain this fact, we may recall that the 

 coal-tar products, as already stated, possess a marked tendency 

 to give rise to suprarenal insufficiency, which sinks sometimes 

 to the stage of blood-disintegration. Lepine has himself ob- 

 served that methsemoglobinuria could follow the use of anti- 

 pyrin. This remedy is now classed among the most active 

 agents at our disposal for the reduction of glycosuria. A 

 remark of Professor Lepine's proves this to be the case in 

 another way. Referring to experiments conducted with the 

 collaboration of Porteret, he says, regarding the action of 



28 L6pine: "Le Diab&te," Paris, 



