PHYSIOLOGY OF THE POSTERIOR PITUITARY. 515 



progressive muscular atrophy, or amyotrophic lateral sclerosis; 

 it has also been mistaken for Charcot's cervical pachymenin- 

 gitis hypertrophica and for erythromelalgia." Referring to the 

 skin, Pirie says: "Its chromatogenous functions are disturbed, 

 much as in rheumatoid arthritis. Small freckles are frequent; 

 patches of a yellowish bronzing occur also on the face, the 

 chest, and the insides of the thighs. (Motais describes a bronz- 

 ing such as occurs in Addison's disease.) Numerous small 

 warts are present. (Mollusca fibrosa are described in many 

 cases and xanthoma-like tumors by Dallemagne.) The patient 

 suffers from a brownish seborrhcea, especially troublesome in 

 the scalp. The hair is thick and coarse and stands straight 

 upward. There is a scanty beard and moustache. Profuse 

 perspirations are constantly complained of. The heart is di- 

 lated. There is tachycardia, the heart beating about 98 to 

 the minute. A soft, systolic, basic murmur is heard at times. 

 Palpitations and fainting fits occur very often. Dyspnoea is 

 marked, and asthmatic-like attacks occur, during which the 

 patient has to sit up in bed and fight for her breath." . . . 

 "The soft parts are remarkably changed as well as the bones. 

 The scalp is much thickened, as is also the skin of the face. 

 . . . In addition to the kyphosis there is a compensatory 

 lumbar lordosis and also a certain degree of scoliosis. The 

 clavicles are enormously hypertrophied. The ribs are thick- 

 ened and expanded, the costal cartilages feel bony, and there 

 are nodular projections resembling the 'rachitic chaplet' at 

 the junctions of the ribs and their cartilages." . . . "With 

 regard to the organs of special senses, the skin of the eyelids 

 is thickened and puffy. The lacrymal glands are hypertro- 

 phied. Increased lacrymation occurs at times, and I have 

 noticed a colloid-like secretion between the eyelids." . . . 

 "There is amblyopia, nearly complete in the left eye, and color- 

 vision for blues and yellows is defective. Bitemporal hemi- 

 anopsia is present. The pupils contract in accommodation and 

 react to light, though very sluggishly in the case of the left 

 eye. With the ophthalmoscope optic atrophy is found." 

 . . . "She suffered much at this time from polydipsia and 

 glycosuria, and for over twelve months there was an almost 

 constant dribbling of saliva from the mouth. . . . The 



