524 THE POSTERIOR PITUITARY AND THE NERVOUS SYSTEM. 



depend for their presence and their amount on the form and 

 method made use of." Demoor employed the same method in 

 each of his comparative experiments and his results were not 

 similar, the non-morphinized specimen alone differing from all 

 others. Hubbard used the identical method in both his com- 

 parative experiments, and likewise obtained results which dis- 

 tinctly showed a marked difference between the rested and 

 fatigued animals. In these and other experiments referred to, 

 the pathogenic agency, including fatigue, was allowed suffi- 

 cient time to produce alterations in the cortical cells, if nutri- 

 tion has anything to do with the process. 



In Weil and Frank's experiments the animals were over- 

 whelmed by the quantity of toxic administered, and death 

 occurred if our views are sound by arrest of the adreno- 

 cardiac functions, long before any marked action upon the cells 

 could possibly have occurred. The doses of morphine admin- 

 istered were 0.38 and 0.41 gramme (6 and 7 grains), respect- 

 ively, with death in 15 minutes; of strychnine nitrate, 0.018 

 gramme (V 3 grain), death in 20 minutes; of hypertoxic urine, 

 125 to 150 cubic centimeters (4 to 5 ounces), death in 15 to 

 25 minutes. That these are overwhelming doses in rabbits is 

 evident. One animal was killed with serum (30 cubic centi- 

 meters 1 ounce) in 5 minutes; others with chloroform inhala- 

 tions in 10 minutes; one by tracheal clamping in 8 minutes. 

 The rest, six animals, were destroyed instantly by instrumental 

 procedures. In none of these animals was there any distinction 

 established as to whether they had been sleeping, eating, or 

 romping, etc. That some were old and others young in the 

 series of nineteen is probable; f as is well known, erethism, espe- 

 cially in such delicate structures, is greatly influenced by age, 

 and a few months in the rabbit represent as many decades in 

 man. The weight of each animal was not recorded in order 

 to establish the relative action of a given dose of the toxic 

 used per pound of animal, though, of course, in the experi- 

 ments, the large doses used precluded any usefulness on this 

 score. 



Finally, the authors themselves will surely admit that "no 

 varicosities," "varicosities," "slightly varicose/' and "very 

 slightly varicose," the method of notation utilized by them, 



