THE LEUCOCYTES IN ORGANIC FUNCTIONS. 681 



of alcohol. The granules become very active and present a 

 characteristic picture." . . . 



"Can these granules be actually seen to leave the leuco- 

 cyte? It is certainly not easy to be sure, even after continuous 

 observation for an hour or more, that one has actually seen one 

 of these granules leave an amoeboid leucocyte. We think, how- 

 ever, that we have observed this phenomenon upon several 

 occasions, both in fresh specimens of blood exposed to 35 C. 

 and in blood to which 1 per cent, of alcohol has been added." 

 Farther on in their text they say: "Many fine granules can 

 be seen in the clear plasma and around the neutrophile, and 

 it would seem that occasionally a granule leaves the active 

 leucocyte and becomes free in the surrounding fluid." 



Bail's observation, however, that the granules actually 

 leave the periphery of- the cell has been sustained by other 

 observers. Gulland refers to this feature of the problem in 

 the following words: "It has often been remarked that the 

 large cells show a great tendency to leave their granules behind 

 them; thus, one might come on a group of granules while the 

 nearest cell was far away. Ballowitz was, I think, the first to 

 declare that all or most of these groups of granules were at- 

 tached to the cell by fine protoplasmic bridges. It is not al- 

 ways easy to show this." Gulland then says, referring to a fig- 

 ure in one of his plates (not shown in that reproduced herein), 

 in which the granules are evidently disunited from the cell: 

 "In the cell shown in Fig. 31, which was so isolated that there 

 could be no doubt that all the granules represented belonged 

 to it, no trace could be made out of threads extending from 

 granule to granule. They were probably stretched too much 

 to allow them to be visible." 



The absolute separation of the granules from the cell wit- 

 nessed by Bail finds its complementary confirmation in the 

 observation of E. B. Sangree, 12 who, after patient watching, 

 sometimes several hours at a time, states that he saw "three 

 granules escape from an eosinophile cell, and wander away until 

 lost under rouleaux of red corpuscles, after having reached a 

 distance of some six diameters from the parent-cell." . . . 



"E. B. Sangree: Philadelphia Medical Journal, March 12, 1898. 



