THE LEUCOCYTES IN ORGANIC FUNCTIONS. 687 



dyes, but the individual granules are small; and the e granu- 

 lation colors only in neutral dyes. 



"The nomenclature of the granules was extended to the 

 cells bearing them. Thus, the various forms of white cells 

 found by Ehrlich in blood were: I. A small cell free from 

 granules, to which the name lymphocyte was given, from the 

 fact that it appears to be developed in lymphoid tissue. This 

 is the small, non-amoeboid form of Max Schultze. II. A cell 

 characterized by possessing fine granules and one or several 

 nuclei. This is by far the most numerous form of white blood- 

 corpuscles in mammalia, and was found by Ehrlich to be neu- 

 trophile in man, and amphophile in rabbits and guinea-pigs. 

 III. The eosinophile cell, or coarsely-granular cell of Wharton 

 Jones and Max Schultze. It occurs only in small numbers in 

 the blood of mammalia, but is abundant in the blood of lower 

 vertebrates. IV. A basophile cell with fine basophile granules 

 (<$ granulation). 



"The mononuclear amoeboid cells of Max Schultze are 

 apparently grouped with the neutrophile cells by Ehrlich. In 

 addition to these forms Ehrlich describes a basophile cell with 

 coarse granules (y granulation), occurring mainly in connective 

 tissues and also in the blood of frogs, but not in the blood 

 of mammals. These he calls 'Mastzellen. . . .' 



"From what we have said so far it will be seen that the 

 group of finely-granular blood-corpuscles described by Max 

 Schultze includes the amphophile and neutrophile and the 

 finely-granular basophile cells of Ehrlich. Since Ehrlich's work 

 no contribution to our knowledge of the morphology of the 

 wandering cells has been made except on points of detail. 

 Mention must, however, be made of the group of cells recog- 

 nized by Metchnikoff 18 in his treatise on inflammation. The 

 term 'leucocyte,' originally applied by the French school of 

 physiologists, is used to designate wandering cells, and the fol- 

 lowing varieties are recognized: (I) lymphocytes; (II) mono- 

 nuclear leucocytes with abundant protoplasm and a round 

 nucleus; (III) polynuclear leucocytes, or 'leucocytes neutro- 

 philes'; (IV) eosinophile leucocytes." 



"Metchnikoff: Loc. cit. 



