704 INTERNAL SECRETIONS AND PRESERVATION OF LIFE. 



granular oxyphile cell, or eosinophile cell, varies in size in dif- 

 ferent animals, not only absolutely, but relatively to the dimen- 

 sions of the other classes of cells. In man it is larger than 

 either the hyaline cell, the finely-granular oxyphile cell, or the 

 finely-granular basophile cell. In the rat, rabbit, and guinea- 

 pig, on the other hand, it is smaller than the largest hyaline 

 cells, but larger than the finely-granular oxyphile and basophile 

 cells. 



"The nucleus is typically an elongated body bent to form 

 a horseshoe. In the rat the arms of the horseshoe are carried 

 so far round that in film preparations the ends often overlap, 

 giving to the nucleus the appearance of a circle with a large 

 hole in the center. Sometimes the nucleus is lobed; but we 

 are inclined to regard this appearance as being largely due to 

 the stresses to which the nucleus is subjected when the cell is 

 dying. In the living cell at rest, when it is spherical, the shape 

 of the nucleus, so far as it can be determined by the disposition 

 of the cell-granules, is a simple horseshoe or crescent. A dis- 

 tinct nuclear net-work is present. 



"Cell-granules. The cell-granules are relatively large, 

 spherical, or slightly ovoid bodies, and are sharply marked off 

 from the cell-substance by their very high refractive index, which 

 is so great that in fluid preparations the granules have a 'brill- 

 iant, greenish luster. 54 The cell-substance in which they are im- 

 bedded has the appearance of a clear, transparent, structureless 

 jelly. The intensity of the oxyphile reaction of these granules 

 differs in different animals, but is always high. Thus, it is very 

 high in the case of the granules of man, these staining with 

 eosin dissolved in 95-per-cent. alcohol. . . . The granules 

 also stain with weak acid dyes, such as Orange G, haBmatoxylin, 

 and sodium sulphindigotate. Ehrlich-Biondi's mixture (washed 

 out with 95-per-cent. spirit) colors these bodies brown-purple, 

 and the 'neutral' mixture (washed out with water) stains them 

 a very intense purple. Corrosive sublimate increases the oxy- 

 phile reaction, as does also heat when applied to the dried 

 film." 



Gulland found Heidenhain's iron-h&matoxylin extremely 



34 All italics other than those of the side headings are our own. 



