710 INTERNAL SECRETIONS AND PRESERVATION OF LIFE. 



the latter is itself traced back to the lymphocyte. "The transi- 

 tion-forms between the finely-granular and the coarsely-gran- 

 ular acidophile cells are seen much more frequently in the 

 bone-marrow than in the blood," says this investigator, "and 

 it seems certain that both from this source and from mitotic 

 division the main source of the eosinophile cells is in the bone- 

 marrow." That there is ample margin for our view that mitosis 

 may occur in the liver is also suggested by the following addi- 

 tional lines: "They must arise elsewhere, however, in abun- 

 dance, for Schaffer 39 and I 40 have shown that they are present 

 in the thymus and in lymphatic glands before either bone or 

 bone-marrow is properly formed at all, and Engel 41 has seen 

 them in the chick's blood on the fifth day of incubation. In 

 the transition-forms (see Figs. 2, 8, 11) there is little in the 

 general shape of the cell and nucleus to distinguish them from 

 the preceding stage." All the evidence tends to show, there- 

 fore, that the process of mitosis through which eosinophile leuco- 

 cytes are formed from neutrophile leucocytes, is carried on in the 

 capillaries of the hepatic lobules, though it can also occur elsewhere 

 in the organism. 



We have referred to the direct path which leucocytes can 

 follow from the liver to the heart and thence to the lungs. If 

 eosinophiles are formed in the liver, therefore, the lungs should 

 show indications of the presence of these leucocytes. Proof that 

 such is actually the case is obtainable with the aid of pathol- 

 ogy: i.e., the significant fact that in several pulmonary diseases 

 eosinophile cells are to be found in the sputum. Teichmiiller, 42 

 for instance, has not only found this to be the case in pulmo- 

 nary tuberculosis, but considers an increase of these cells favor- 

 able from the standpoint of prognosis. In asthma, though a 

 non-ulcerative process is present, eosinophiles are to be found 

 in abundance in the sputum, and Gollasch 43 states that they are 

 connected with the formation of the Charcot-Leyden crystals. 



88 The italics are our own. 



Schaffer: Centralbl. fur die med. Wissen., 1891. 

 "Gulland: Journal of Path, and Bacteriol., 1894. 

 41 Engel: Archiv f. mikr. Anat., vol. Ixiv, 1894. 



"H. Lenhartz: "Manual of Clinical Microscopy," advance pages of transla- 

 tion by H. T. Brooks, Post-graduate, July, 1902. 

 "Gollasch: Fortschritte der Med., vol. 1889. 



