158 YEASTS; BUDDING FUNGI; SACCHAROMYCES. 



of a typhus patient ; in pus from a case of otitis media ; in the 

 pseudomembrarious angina occurring in a typhoid patient. 



According to Demme, Saccharomyces ruber, occurring on 

 red raspberries, was the cause of a severe epidemic of intes- 

 tinal catarrh. 



Busse, in 1895, found a pathogenic blastomyces in a large 

 swelling of the tibia, which on microscopic examination 

 showed a sarcomatous structure. The fungus was obtained 

 from the tumor and isolated in culture. The blastomyces 

 nodules resemble sarcomatous growths very closely. 



The yeast-cell may be mistaken for a tumor-cell inclusion, 

 which is seen so frequently in malignant growths. This find- 

 ing is the reason for the belief that the blastomyces is the 

 cause of malignant growths. The conclusions arrived at are 

 based on a series of experiments conducted by several promi- 

 nent pathologists, but a careful and unbiased analysis of 

 their results forces us to the conclusion that the occurrence 

 of yeasts in malignant growths is purely incidental and acci- 

 dental, and should not be looked upon as an etiologic factor or 

 even as a contributing cause. 



Gilchrist, in 1884, and other investigators later, found the 

 blastomyces or yeast fungus in certain peculiar skin affections. 

 The pathology was that of scrofuloderma, a chronic diffuse 

 inflammation. The yeast fungus was obtained in each case 

 and cultivated. The disease is known as cutaneous blasto- 

 mycosis or blastomycetic dermatitis. We mention these facts 

 in order to impress the reader with the importance, clinically, 

 of the yeast fungi, and to encourage research work in this 

 direction. 



