42 PHYSICOCHEMICAL PROPERTIES 



By comparing the doses of this second experiment with 

 those of the first, that is to say, by recognizing the large 

 proportion (three-quarters) of luargol fixed by the cells of 

 the blood in a mixture in vitro and the very small proportion 

 (one-sixteenth) found in the coagulum in the injected rabbit 

 twenty-four hours after the injection, we may assume that 

 the largest part of the luargol remaining in the organism has 

 been fixed by other elements, probably by leukocytes and 

 transported to the liver, spleen, and to the hemopoietic 

 organs. 



By estimating the arsenic eliminated day by day following 

 a single injection, Mile. Michel found in certain cases traces 

 of arsenic in the urine twenty-four days after the injection 

 of a dose of 10 eg. in a rabbit weighing 2500 gm. In these 

 cases the elimination is not regular but takes place by suc- 

 cessive discharges (Emery and Jeanselme) at intervals of 

 three, four or even eight days. The largest quantity is 

 eliminated in the first sixty hours. By estimating the total 

 quantity of eliminated arsenic, we find that up to some 

 tenths of a milligram, the organism retains none of an arsenic 

 compound injected as luargol. 



In man therapeutic doses of luargol exactly disodic (5 to 

 30 eg.) never provoke primary reactions but very small doses 

 of 5 to 10 eg. may produce a slight reaction of another nature, 

 rarely in two to three hours, generally in twelve to twenty- 

 four hours after the injection. These reactions are mani- 

 fested generally only after the first injection and consist of a 

 mild and transient fever (38 to 38.5 C.) for one to two hours 

 accompanied sometimes by chills and mild headache, very 

 rarely by nausea and diarrhea, corresponding to the fixation 

 of the product by the cells. The nature of the symptoms 

 leads us to suppose principally a reaction of the cells of the 

 central nervous system. 



There is not generally a reaction to the second injection 

 nor to following injections even if the doses are progressively 

 increased because as we have seen above the elimination of 

 the product is very slow so that each of the successive doses 

 may be considered as a preparation or vaccination for the 

 following injection. There is even a sort of tolerance or a 



