PHYSICOCHEMICAL PROPERTIES 43 



cellular immunity identical to that which is observed to 

 toxins and other biologic antigens. Cells multiply their anti- 

 bodies and may transform larger and larger quantities of 

 antigen (up to a certain limit) without being disturbed in 

 their normal functions. 



Thus as far as it is possible to judge by repeated daily 

 analyses of urine and intestinal contents, of blood, organs 

 and tissues in a series of animals from the time of injection 

 to the total elimination of the injected product, we may 

 assume that arsenobenzene injected into the blood as a 

 soluble colloid passes partially as a precipitate into the 

 organs (liver, spleen, etc.) and partially as a solution into the 

 cells of different tissues where it becomes insoluble. That 

 part fixed by organs and tissues is transformed either into 

 soluble crystalloids which again pass into the blood and are 

 eliminated by the kidneys and intestines, because they have 

 no longer any affinity for the contents of the cells, or into 

 soluble semi-colloidal products which also pass into the 

 circulation but may again be fixed by the cells to be finally 

 transformed into neutral salts and eliminated as such. Some 

 of the injected arsenobenzene is transformed directly in the 

 blood to a neutral salt which is rapidly eliminated without 

 passing through the tissues. It is this last portion which 

 forms the primary discharges of the product eliminated in 

 the first twenty-four hours and which marks the first summit 

 of the elimination curve. The second summit which is 

 generally ended on the third or fourth day after the injection 

 indicates the second discharge of the product which has been 

 fixed and dissolved in the organs and tissues. Little summits 

 which are noted up to the tenth and thirteenth day corre- 

 spond to little successive discharges of the product which 

 have once or twice been refixed and redissolved in the tissues. 



SUMMARY. Arsenobenzene is an arseniated or arseno- 

 antimonious or multimetallic amine which in the form of a 

 sodium compound does not exist as a free molecule but w r hose 

 component molecules in greater or less number, form col- 

 loidal granules. When injected into the blood, the colloidal 

 granule passes through a series of transformations which 

 lead to its disintegration and to the liberation of its molecules. 



