TUBERCULOSIS 61 



of local rupture the tuberculin thus liberated provokes a con- 

 gestive reaction in all the other foci; quite as an artificial 

 injection of. tuberculin. 



5. Each of these impulses may be followed by a definite 

 recovery, thanks to the intervention of antibacillin or by an 

 aggravation of the disease caused by the bacteria thus 

 liberated and not destroyed, which become centers for new 

 foci and new lesions. 



6. Immunity acquired by the healing of a spontaneous 

 or artificia 1 infection is of short duration, most probably 

 because the production of antibacillin is rapidly stopped after 

 the disappearance of bacteria. 



7. We may consider it as proved that the presence of living 

 avirulent bacteria in the organism confers on cattle a com- 

 plete immunity against virulent reinfections. 



TUBERCULOSIS MAY BE CHARACTERIZED in the following 

 manner: 



Disease of local infectious foci which may give rise to septi- 

 cemic metastases. 



Antigen soluble (tuberculin), non-pathogenic for normal 

 tissues as it cannot be fixed by antibodies en surcharge. 



Normal antibody intracellular can multiply in the cells in 

 excess and remain fixed in the interior of cells "en surcharge." 



Intracellular antibody "en surcharge" (antituberculin) is 

 pathogenic for the cells hypersensitiveness non-specific. 



Intracellular compound of normal antibody and antigen is 

 non-pathogenic (digestible) and causes the multiplication of 

 antibodies. 



Intracellular compound of antibody en surcharge and of 

 antigen is pathogenic (non-digestible) for the cells and causes 

 the destruction of the cells. 



Bacterial antigen (bacterial bodies cause the formation of 

 a specific agglutinating antibody (antibacillin) . 



Antibacillary immunity not antitoxic immunity. 



Intracellular anaphyJaxis and not intravascular anaphylaxis. 



From the total of the theories which we have just reviewed 

 are forced to conclude that in tuberculosis it may not only 



