120 THERAPEUTIC MEASURES 



606 and galyl for Trypanosoma gambiense, Rhodesiense and 

 Surra but they are less active for nagana. The product 

 No. 219 is the only one with which up to the present time it 

 is possible to destroy the trypanosome dimorphon in the 

 blood of mice. The principle is probably similar to that of an 

 antitrypanosome serum which causes agglutination of the 

 parasites. 



3. In infectious lymphangitis, galyl (of Mouneyrat) is 

 much more active than 606 or luargol. 



4. In bacterial septicemias (acute and chronic) all these 

 products are of equally little efficacy. The injection of 606 

 may prevent the development of anthrax when injected at 

 the same time or very shortly after the virus, but luargol in 

 which the bromide is replaced by the iodide of silver is much 

 more active than 606, probably on account of the specific 

 action of the iodine. A prolonged treatment with the product 

 219 has brought about the fairly rapid recovery (two to three 

 months) of several severe cases of generalized glandular 

 tuberculosis. 



The conclusions which these facts suggest are: 



1. Although the action of every arsenobenzene is equally 

 anti-anaphylactic, that is to say, causes in the organism 

 reactions of the same sort, the substances of the organism 

 and the substance of the infecting parasites which react with 

 the drug are not the same for each drug. By multiplying the 

 different affinities of the product the fixation and neutraliza- 

 tion of a much larger number of different substances of the 

 parasite is brought about and thus the field of action of the 

 product is extended to a greater number of parasites. 



For example, if 606 acts only by the free affinities of its 

 arsenic, 219 may act by its own affinities of arsenic and in 

 addition by those of antimony, bromine, silver and copper. 



2. It is probably not necessary to complicate the composi- 

 tion of therapeutic products by elements with great anti- 

 toxic or antiseptic power as these might in the long run 

 become themselves dangerous for the tissues. 



It is true that certain organic compounds (toxins, venins, 

 sera) are more pathogenic than the most toxic metallic salts 

 but since it is a question of obtaining anaphylactic effects 



