174 ANTI-ANAPHYLACTIC TREATMENT OF DISEASES 



pause, a large number of gastrointestinal disturbances 

 including several forms of enteritis and chronic diarrhea, 

 gastroptosis, neuro-arthritis, rheumatism and the gastro- 

 intestinal symptoms of tuberculosis. 



SUMMARY OF OBSERVATIONS. 



Two hundred and sixty cases of chronic disease, similar to 

 those quoted were treated in this manner (with the collabora- 

 tion of Drs. Cazin, Dalimier, Delettre, Dominici, Labonnette, 

 Raspali, Richard, Smiechowska, and others). 



In analyzing these cases, one finds from the first that the 

 treatment by antigens prepared from the germs of intestinal 

 flora, showed itself efficient, not only in cases of digestive 

 disturbance and in urticaria, but also in many other cases, 

 which appear to have no direct relation with the functions of 

 the digestive apparatus. We must, therefore, conclude that, 

 even if the primary causes of these diseases differ, the reactions 

 determining the pathologic symptoms must always be of the 

 same nature. 



On the other hand, the minuteness of the curative doses 

 (2 to 3 mg. by mouth and a few hundredths of a milligram in 

 hypodermic injections) and the rapidity of the reactions 

 caused by these doses, suggest that the bacterial antigens 

 contain a much greater proportion of the active substance 

 than peptone, animal proteins, milk or any serum which in 

 certain cases of urticaria, asthma (Widal, Nolf, Paignez and 

 Vallery-Radot Pasteur, and others), give similar curative 

 results in doses a hundred or a thousand times greater. 



The action of the bacterial preparations which were used 

 in the cases quoted above were probably not "specific," 

 in the sense of the antigens used in the vaccinotherapy of 

 Wright, but their actions are remarkably selective. 



GENERAL AND LOCAL REACTIONS CAUSED IN THE 

 ORGANISM BY ENTERO- ANTIGENS. 



Action on the Intestinal Flora. W T e have already seen that 

 the injections or the ingestion of our preparations, at the 



