176 ANTI-ANAPHYLACTIC TREATMENT OF DISEASES 



never last long, are not a centra-indication to further treat- 

 ment, and are always followed by appreciable and rapid 

 improvement. At the most, it may sometimes be necessary 

 to diminish the dose. If this is necessary only one-tenth or 

 even one-hundredth is given. 



Local Reactions. When the treatment is applied in the 

 form of injections, the reactions at the point of inoculation 

 vary considerably. Sometimes redness, and a more or less 

 painful zone may persist for one to three days: at other 

 times the injection leaves no other trace than the small 

 needle point. 



If the treatment is by ingestion, one often notes, on the 

 first and second days a slight pain in the epigastrium. This 

 pain is only slight and manifests itself only on pressure in 

 the epigastrium. 



Whether the treatment is applied by injection or by inges- 

 tion, palpation discloses a sensitiveness over the gall-bladder 

 and over the posterior part of the liver between the eleventh 

 and twelfth ribs, near the upper edge of the right kidney. 



The kidney is never tender, but undergoes important 

 functional modifications. A phenomenon is observed similar 

 to that which often characterizes the terminal period of acute 

 infections (typhoid fever, influenza), namely, polyuria. 



The reaction on the gastro-intestinal functions is quite 

 remarkable. No matter what the preparation, autogenous 

 or heterogeneous, or whether administered by injection or 

 by ingestion, it acts as a regulator of the digestion and of 

 evacuations. 



In those cases where gastro-intestinal functions are normal, 

 for instance in psoriasis, the beginning of the treatment is 

 characterized by a tendency toward constipation, which 

 may last several days and recovers spontaneously without 

 medication. 



The circulation is also influenced by the action of the 

 entero-antigens. In the cases of either increased or decreased 

 blood-pressure, one often sees hypertension diminish by 10, 

 20 or 30 mm. and hypotension increase by 10 or 20 mm. 

 after the treatment. 



