ACTION OF CERTAIN DRUGS 291 



fact that acids interfere with the activity of the kinetic 

 system. In every case extensive histologic changes 

 were seen in the brain, the adrenals and the liver; 

 and iodin determinations gave evidence of the fact 

 that there was increased thyroid activity also. 



A. B. c. 



Section of normal Section of adrenal of Section of adrenal of 



adrenal of cat. cat after injection of cat after injection of 



acid sodium phosphate, sodium bicarbonate. 



FIG. 72. THK COMPARATIVE EFFECTS OF AN ACID AND OF AN ALKALI 

 ON THE ADRENALS OF CATS. 



Note the disappearance of cytoplasm in C, and the eccentric and crenated 

 nuclei as compared with the nearly normal appearance of C. 



(From photomicrographs, X 1640.) 



On the other hand after the administration of an 

 alkali sodium bicarbonate histologic studies of the 

 brain, the adrenals and the liver showed a hyper chro- 

 matic condition corresponding to the hyperchromatic 

 condition produced by the administration of morphin 



