296 MAN --AN ADAPTIVE MECHANISM 



structive effect of ether was found in laboratory studies 

 on the effect on animals of the simultaneous adminis- 

 tration of an infection diphtheria toxin with ether 

 or with nitrous oxid. 



In animals which received a dose of diphtheria 

 toxin and were kept under ether anesthesia for four 

 hours, greater histologic changes were produced in the 

 brain, adrenals and liver than were found in other 

 animals given a like dose of diphtheria toxin but not 

 anesthetized at all. On the other hand, in animals 

 given diphtheria toxin and kept for four hours under 

 continuous nitrous oxid anesthesia, the cells of the 

 brain, adrenals and liver not only were unchanged, but 

 in some instances were hyperchromatic, corresponding 

 closely to the cells of these three organs in animals which 

 had been subjected to diphtheria toxin and morphia, 

 or to sodium acid phosphate and sodium bicarbonate. 

 (Figs. 74, 75, 76.) 



This evidence shows that by the simultaneous use 

 of morphia and nitrous oxid, as in the operation under 

 anociation, the greatest possible protection has been 

 given to the kinetic system. 



Summary 



Thus, at will, by the administration of certain drugs, 

 the kinetic organism of man and animals may be acceler- 

 ated, retarded or its action suspended. 



Thus, at will, by the use of drugs we may produce 

 in the organism phenomena which resemble those 

 produced by fever, infection, emotion, etc., and in like 

 manner the phenomena of sleep or death may be 

 produced. 



