EXTRACTUM GLYCYRRHIZ^E 2 29 



Powder. Characteristic elements: See Part iv, Chap. I, B. 



CONSTITUENTS. Glycyrrhizin, asparagin, glycyramarin, an acrid resin, 

 starch, etc. Glycyrrhizin is a glucosid, sparingly soluble in alcohol 

 and ether, splitting up by hydrolysis into sugar and a brownish- 

 yellow bitter substance, glycyrrhetin; it probably exists in combination 

 with ammonia. Ash, not to exceed 7 per cent. 



Preparation of Glycyrrhizin. Obtained from the cold infusion (from which 

 albumen has been removed by heat) by precipitating with H 2 SO 4 . Purify pre- 

 cipitate by dissolving in very weak ammonia water i to 10, filtering, and evaporat- 

 ing. 



ACTION AND USES. Expectorant and demulcent in bronchial affections. 

 Frequently used to disguise the disagreeable taste of other medicines, 

 and as a sweetening ingredient for medicinal preparations. Dose: 

 15 to 60 gr. (i to 4 Gm.). 



OFFICIAL PRERAPATIONS. 



Fluidextractum Glycyrrhizae, Dose: 15 to 60 njj (i to 4 mils). 



Extractum Glycyrrhizae Purum, 5 to 60 gr. (0.3 to 4 Gm.). 



Mistura Glycyrrhizae Composita (3 

 per cent, of extract, with wine of 

 antimony, paregoric, sweet spirits 

 of niter, syrup, and mucilage of 



acacia), 2 to 6 fl. dr. (8 to 24 mils). 



Glycyrrhizinum Amrnoniatum, 5 to 15 gr. (0.3 to I Gm.). 



Pulvis Glycyrrhizae Compositus (23.6 

 per cent., with senna, washed sul- 

 phur, oil of fennel, and sugar), J^ to 2 dr. (2 to 8 Gm.). 



Elixir Glycyrrhizae. 



230 a. EXTRACTUM GLYCYKRHIZ^ Extract of Licorice. Made 

 by evaporating the aqueous extract of the root. It is found 

 in market in black, brittle, cylindrical rolls about 150 mm. (6 in.) 

 long; flexible when warm, but when dry breaks with a brittle, con- 

 choidal fracture, showing a glossy surface; odor characteristic; taste 

 sweet. It yields a brown powder. It contains glycyrrhizin, both 

 free and combined with ammonia, to which combination its sweetness 

 is due, glycyrrhizin itself being almost tasteless. It is an excellent 

 demulcent, the presence of a small piece in the mouth often allaying 

 cough by coating and thus protecting the irritated membrane.' Not 

 less than 60 per cent, of the extract of glycyrrhiza should be soluble 

 in cold water. Dose: 15 to 60 gr. (i to 4 Gm.). Ash, not more than 

 6 per cent. 



OFFICIAL PREPARATIONS. 



Trochisci Ammonii Chloridi (each troche containing 



about 3 grains each of glycyrrhiza and i^j of 



ammonium chloride, with sugar, tragacanth, and 



syrup of tolu), Dose: I or 2 troches. 



Trochisci Cubebae. 



