462 SEROTHERAPY 



tional precaution, but this dressing should not take the place of subcu- 

 taneous injections of the liquid preparation in wounds likely to be infected 

 with tetanus. Its actions and uses are the same as those of tetanus, 

 antitoxin, unconcentrated. 



POLLANTIN, FALL. Dunbar's Serum-Antitoxic serum from horses 

 treated with pollen toxin derived from ragweed. 



Pollantin, fall, has no pharmacologic action except the neutralization 

 of the pollen toxin. The serum is not intended for use hypodermically. 

 It is employed for the relief of hay fever and it seems to be effective in a 

 proportion of cases. It may be used as a prophylactic. 



One drop should be instilled by means of a pipette into the outer angle 

 of each eye and one or two drops into one nostril, the other being closed, 

 every morning before rising. If the first application causes sneezing or 

 reddening of the mucous membrane of the eye, the directions are to repeat 

 the application, even for the fourth time, if necessary. 



POLLANTIN POWDER, FALL. A powder obtained by evaporating in 

 vacuo pollantin serum derived from ragweed toxin at about 45C., and 

 mixing it with sterilized sugar of milk. 



The action and use is the same as those of the liquid. 



The powder is applied to the eyes by dusting on the conjunctiva and 

 to the nose by snuffing into one nostril, the other being closed, a piece as 

 large as a lentil. 



SERUM ANTIDIPHTHERICUM PURIFICATUM,U.S.P. A trans- 

 parent or slightly opalescent liquid with sometimes a slight granular or ropy 

 deposit, -odor less, or having an odor due to the presence of the antiseptic 

 used as a preservative. The liquid is sometimes more or less viscous. 

 The serum must come from healthy animals, must be sterile, must be free 

 from toxins and other bacterial products, and must not contain an excess- 

 ive amount of preservative (not more than 0.5 per cent, of phenol or 0.4 

 per cent, of cresol, when either of these are used), and the total solid 

 must not exceed 20 per cent. Serum of a lower potency than 250 units 

 per mil must not be sold or dispensed. Purified antidiphtheric serum 

 must comply with the requirements for loss of potency, control labeling 

 and standard for potency under Serum Antidiphthericum. 



This serum is prepared from unconcentrated diphtheria antitoxin by 

 the separation of the pseudoglobulins with which the antitoxin molecule 

 seems to be particularly associated. The elimination of most of the other 

 elements of the horse-serum reduces the bulk for a given unit value and 

 probably diminishes the frequency and intensity of the urticarial rashes. 



This preparation consists of a solution of certain antitoxin proteins 

 in physiologic sodium chloride solution. These proteins are obtained by 

 adding ammonium sulphate to the original serum, and treating the precipi- 

 tate with saturated sodium chloride solution; the antitoxins pass into 

 solution and much inert material remains in the undissolved portion of the 



