SUPRARENALTJM SICCUM 477 



of milk sugar. In exophthalmic goiter this preparation causes a reduction 

 of the swelling and of the pulse rate, and an increase of body weight. 



ANTITHYROIDIN SERUM ANTITHYROIDEUM. The blood serum of sheep 

 from which the thyroid gland has been removed at least six weeks before 

 the blood is drawn, preserved by the addition of 0.5 per cent, of phenol. 



DOSAGE. It is administered by the mouth in doses beginning with 

 0.5 to i mil three times a day, gradually increasing the dose as necessary. 



THYREOIDECTIN. Gelatin capsules, each containing 0.33 Gm. of 

 a powder prepared from the blood of thyroidectomized animals. Dose: 

 one or two capsules, three times a day. 



SUPRARENALUM SICCUM, U.S.P. The suprarenal glands of 

 animals which are used for food by man, cleaned, dried, freed from fat, and 

 powdered, and containing not less than 0.4 per cent, nor more than 0.6 per 

 cent, of epinephrine, the active principle of the suprarenal gland. One 

 part of dried suprarenal represents approximately 6 parts of fresh glands, 

 free from fat. 



It is a light yellowish-brown amorphous powder, having a slight charac- 

 teristic odor, partially soluble in water. Assayed by U.S.P. method. 

 The average dose is 0.25 Gm. 



PURIFIED EXTRACT or ADRENAL GLAND. An extract of the suprarenal 

 gland, standardized physiologically by measuring its effect on blood pres- 

 sure and so adjusted as to correspond to the effect of 4 per cent, of purified 



PIG. 262. Suprarenal Capsules ( natural size.) (Photograph.) 



epinephrine. It has therefore approximately four times the strength of 

 desiccated suprarenal gland U.S.P. 



EPINEPHRINE is a substance, with feeble basic properties, obtained 

 from the suprarenal gland of the sheep or other animal; also made syn- 

 thetically. Its most important therapeutic actions consist in a constric- 

 tion of the blood-vessels, with consequent high rise of blood pressure; 

 a stimulation of the vagus center, with slowing of the heat, and a direct 

 stimulant and tonic effect on the heart muscle, similar to digitalis. 

 Large doses also cause glycosuria. Its chief use is locally in hemorrhage 

 and in catarrhal and congestive conditions. The dose is 0.3 to 2.0 mils 

 of a i to 1000 solution, every two or three hours. 



