ADRENALS 659 



epinephrin given off per minute varied from o-ooi milligramme to 0-002 

 milligramme. All the epinephrin seems to be contained in the plasma 

 and none in the corpuscles (Figs. 210, 211). 



Fig. 210. Comparison of Effect of Adrenal Vein Blood and its Sediment on Rabbit's 

 Intestine Segments, n, Ringer replaced by indifferent blood, and this at 12 

 by adrenal vein blood. 13, Ringer replaced by sediment of indifferent blood, 

 and this at 14 by sediment of adrenal vein blood. The bloods and sera were 

 diluted with 2 volumes Ringer. Time-trace, half-minutes (reduced to one-half). 



If we suppose that a cat, weighing 2*5 kilos, and containing 200 c.c. 

 of blood was giving off o-ooi milligramme of epinephrin per minute, the 

 concentration which this output would maintain in the mixed blood, 

 supposing that there was no loss in passing through the lungs and up to 

 the systemic capillaries, would be at most only i : 400,000,000 or 

 i : 500,000,000. For at least 400 or 500 c.c. of blood would pass through 



Fig. an. Effect of Adrenal Blood (16), Serum (15), and Sediment (18), OH Rabbit's 

 Uterus Segment. All the specimens were diluted with 5 volumes Ringer. 



the heart in one minute. Now with such concentrations of adrenalin 

 no known reaction has ever been demonstrated in the normal intact 

 animal. Of course, in the cava pocket experiments described above, 

 the concentration in the blood will be much greater because a relatively 

 considerable quantity of epinephrin-containing blood is accumulated 

 in the pocket and then suddenly discharged. 



