462 



BULLETIN OF THE BUREAU OF FISHERIES. 



3002 B. The amount of thyroid tissue surrounding the vessels is very scarce. Vesicles small, epithelium flattened, filled with 

 itainable colloid. Normal thyroid. 



3003 A. Alveoli small and Uned with high columnar epithelium, deeply staining nuclei. Colloid absent. Follicles few ia 

 niunber and poorly staining. Occasional groups of vesicles of normal appearance. Beginning invasion of areolar tissue. Dense 

 connective tissue structure. Growth into bone cavities. Definite alvcolo-tubular type beginning carcinoma. 



3004 A. B, C. Space about vessels rather well filled with small-sized vesicles relatively uniform in size. Epitheliimi is flat, 

 tcned. Vesicles are filled with stainable colloid. In one small area close to a large vessel area half dozen follicles in which the 

 colloid is small in amount, the epithelium cubical. Normal thyroid. 



2005 A. This is evidently one of the tumor fish introduced into this experiment. Large amount of thyroid tissue. Great 

 variability in the size of the follicles. Large regular shaped follicles lined with flattened epitheUum and filled with stainable colloid. 

 Large numbers of small follicles with cubical or flattened epithelium. Varying amount of colloid. Large amount of hyaline con- 

 nective tissue stroma. Obviously a tumor which has undergone regression. Tumor tissue fills the entire space around the vessel, 

 penetrates to the floor of the mouth, and into the bone cavities. It has previously invaded and destroyed large areas of muscle. 

 Contains numerous nematode tubercles, in which no worms are to be found. Spontaneous recovery. See further under that 

 heading. 



2005 B. Very few follicles included in this section. Flattened epithelium filled with stainable colloid. Typical vesicles. 

 Normal, 



200s C. Evidently tumor fish introduced into this experiment with spontaneous recovery like aoos A. Contains two nema- 

 tode tubercles, in one of which remnants of a worm can be seen. 



2006 A. B. Thyroid consists of typical vesicles with flattened epithelium filled with stainable colloid. Normal. 



2007 A. Space around the large vessels contains scattered follicles filled with stainable colloid, Uned for the most part with 

 flattened epithelium. There is marked hyperemia, marked engorgement of the vessels between the follicles, and evidence of 

 small extravasation about the follicles. A few follicles are Uned with cubical epitheUum. Hyperemia of the thyroid, possibly- 

 beginning hyperplasia. 



2007 B. Tissue badly preserved, evidently overheated in embedding. Shows section of media of aorta around which arc 

 areas of closely packed large follicles, lined with cubical eptheUum. No coUoid. Beginning hyperplasia. 



2008 A, B. Small foUicIes Uned with flattened epithelium, filled with stainable colloid. Normal. 



2cx>8 C. Thyroid tissue in this fish consists of rather compact masses in the region of the large vessels. The epithelium of 

 some folUcles is sUghtly cubical. FoUicles are filled with stainable colloid. Some evidence of hyperemia in the vessels between 

 the folUcles. SUght hyperemia of the thyroid. Probably normal. 



2009 A, B. Follicles oval and spherical, Uned with flattened epitheUum, fiUed with stainable colloid. Normal. 



2010 B. Vesicles lined with flattened epithelium, filled with stainable colloid. Normal. Aroimd the large vessels the thyroid 

 foUicles are closely packed; the coUoid is reduced in amount but stains deeply. EpitheUum is small, cubical. Probably normal. 

 Thyroid tissue greatly increased in amount but of normal appearance. 



2010 C. Spherical and oval follicles lined with flattened epithelium filled with stainable colloid. Normal. 



201 1 A. FolUcles Uned with flattened epitheUum, filled with stainable colloid. Between the folUcles hyperemia of the ves- 

 sels. Some evidence of extravasation. Hyperemia of the thyroid. Probably normal. 



2011 B, C. Spherical and oval folUcles Uned with flattened epithelium, filled with stainable colloid. Normal. 



2015 B. Closely packed foUicles of irregular shape with almost complete absence of coUoid. FolUcles lined with cubical 

 epithelium. SmaU groups of detached follicles lying outside the closely packed area lined with flattened epitheUum and fiUed 

 with stainable colloid. First evidences of hyperplasia. Beginning simple hyperplasia. 



2015 C. Between the second and third gill arches the space is filled with loosely arranged folUcles, many of which contain 

 stainable colloid and are Uned with sUghtly cubical epithelium. Between the folUcles, marked hyperemia and engorgement of 

 the vessels. Away from this mass in this area of slightly altered thyroid one finds isolated typical normal folUcles with deeply 

 staining colloid and flattened epitheUimi. Again, about the aorta above and below it. one finds one or two aggregates of folUcles 

 with slightly cubical epitheUum and evidences of hyperemia. The remainder of the thyroid tissue about the large vessels strictly 

 normal. Hyperemia of the thyroid, possibly beginning hyperplasia. Unusual amount of thyroid tissue. 



2098 A. Tumor. Typical alvcolo-soUd carcinoma for the most part, with areas of papillary formation. Infiltration of muscle, 

 bone, and cartilage. Infiltration of wall of vein. Papillary adenoi-carcinoma infiltrating muscle bone and cartilage. HyaUne 

 degeneration of the wall of the media of the aorta. (Fig. 90.) 



2098 B. Beginning adeno-carcinoma of tubulo-alveolar type. Infiltration of areolar tissue, dense connective tissue structures. 

 periosteum of bone and muscle. 



2099 A. Examination of this section shows an unusual amount of thyroid tissue about the large vessels, small follicles lined 

 with flattened epithelium, some of them containing stainable colloid, others poorly stained colloid, many of them empty, pushed 

 in flattened strands between the dense connective tissue structures, spreading well forward into the areolar tissue and in the 

 adjacent bone cavities. (Fig. 91.) Great increase in the amount of thyroid tissue. Only one or two large follicles filled with 

 stainable colloid. Immediately adjacent to the large vessels a few follicles with high cubical epitheUum and no colloid. The 

 whole specimen indicates the previous existence of weU-developed hyperplasia followed by regression. 



2099 B, C. Presents the same histological characteristics. Increased amount of thyroid tissue. Many isolated groups 

 widely distant from the large vessels. About the large vessels are many tortuous elongated and branching alveoU of tubular 

 type, Uned with flattened epitheUum, free from colloid. (Fig. 92, under "Spontaneous Recovery.") Colloid almost entirely 

 absent. 



