CHOLERA, PLAGUE, TYPHOID FEVER 129 



came many years of laboratory work : then, the 

 results of that work in practice. The discovery of 

 Widal's reaction ; the discovery of protective in- 

 oculation ; the anti-typhoid campaign led by Koch 

 in Germany ; the recognition, in all countries, of 

 the risk from typhoid- carriers ; and the study of 

 para-typhoid fever all these great lines of research 

 have been followed by a multitude of workers : 

 but there is not room here for more than a short 

 note on protective inoculation.* 



Protective Inoculation. 



The name of Sir Almroth Wright stands first, 

 all the world over, for this method of treatment : 

 but many names are memorable Sir William 

 Leishman and Major Harrison in India, Major 

 Russell in America, Pfeiffer and Kolle in Germany, 

 Chantemesse and Vincent in France : these, and 

 many more. 



The first use of the treatment in our country 

 was in July- August, 1896, at Netley Hospital, by 

 Wright and Semple, on 18 men who tried it on 

 themselves f : 



* For further reading, no better guide one might almost 

 say, no better reading could be found than Ledingham and 

 Ark wright on The Carrier Problem. 



t See Lancet, September 19, 1896, and Brit. Med. Journ., 

 January 30, 1897. In Germany, about the same time, 

 Pfeiffer and Kolle published cases treated. See Deut, Med. 

 Woch., November 12, 1896. 



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