XII. IS IT POSSIBLE BY INJECTING AGGLUTINATED 



TYPHOID BACILLI TO CAUSE THE PRODUCTION 



OF AN AGGLUTININ? 1 



By Prof. M. NEISSER, Member of the Institute, and Dr. R. LUBOWSKI, formerly 

 Assistant in the Bacteriological Division. 



ESPECIALLY important for Ehrlich's conception of the chemical 

 union of toxin and antitoxin are the experiments in which immu- 

 nization of animals was attempted with neutral, and therefore non- 

 poisonous, toxin-antitoxin mixtures. Such experiments, inaugu- 

 rated by Babes, were recently published by Kretz, 2 among others. 

 At first it appeared to this author that he could really immunize 

 with such neutral mixtures, but exact reexamination convinced him 

 of the contrary. Jules Rehns 3 also was unable to obtain any results 

 with neutralized toxin-antitoxin mixtures. All of these experi- 

 ments showed that Ehrlich's conception, that of a chemical union 

 of toxin and antitoxin, most readily sufficed to explain the facts. 



In immunization with cellular material the circumstances are 

 far more complex, von Dungern 4 therefore first attempted to 

 rule out the immunizing action of the injected cells (erythrocytes) 

 by simultaneously injecting the Corresponding immune serum obtained 

 elsewhere. This mixture, therefore, was neutral, and caused no 

 immunity reaction. Our colleague, Dr. Sachs, has continued these 

 researches at the suggestion of Professor Shield, and will report 

 thereon the following article. 



In direct contrast to v. Dungern's experiments are the results 



1 Reprint from the Centralblatt f. Bacteriologie Parasitenkunde und Infec- 

 tions Krankheiten, Vol. XXX, 1901, No. 13. 



2 R. Kretz, Ueber die Beziehungen von Toxin und Antitoxin, Zeitschr. f. 

 Heilkunde, 1901, No. 4. 



3 See pages 143 et seq. 



4 See pages 36 et seq. 



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