594 COLLECTED STUDIES IN IMMUNITY. 



for such receptors to be thrust off normally. In view of the great 

 diversity of substances which we are able to produce by artificial 

 immunization, it should not surprise us to encounter a great variety 

 of substances in normal serum. When we consider, further, how 

 varied is the behavior of different species and even of different 

 individuals of the same species, we shall at once associate this with 

 the great divergence in the content of normal antibodies in different 

 species and different individuals. As a matter of fact these varia- 

 tions are no greater than the variations in hairiness or in pigmen- 

 tation. 



Further experimental investigations will surely reveal the presence 

 of many more antibodies in normal serum, and it is possible that 

 additional clinico-experimental studies may even give us the 

 ,key to their physiological function. An insight into their signifi- 

 cance in man might open up new ways in diagonosis and therapy. 



LITERATURE. 



1. BAIL, Archiv fur Hygiene, 1899, Vol. XXV, page 284. 



2. BORDET, Annales Pasteur, Vol. XII, No. 10. 



3. BORDET, Annales Pasteur, 1899, Vol. XIII, page 225. 



4. BUCHNER, Centralblatt Bacteriologie, Vol. V, page 817; Vol. VI, page 1. 



5. BUCHNER, Miinchener med. Wochenschr. 1900, Nos. 9 and 35. 



6. COBBETT, Centralblatt Bacteriologie, 1899, Vol. XXVI, page 548. 



7. EHRLICH, Berlin, klin. Wochenschr. 1898, No. 12 (Ges. d. Charite" Aerzte, 



Feb. 3.) 



8. EHRLICH, *The Croonian Lecture, Proceed. Royal Soc., Vol. LXVI, page 424. 



9. EHRLICH, Semaine medicale, Dec. 6, 1899. 



10. EHRLICH and MORGENROTH, Berlin, klin. Woshenshcr. 1900, No. 1. 



11. EHRLICH and MORGENROTH, Berlin, klin. Wochenschr. 1900, No. 31. 



12. KRAUSS, Wiener klinische Wochenschr. 1900, No. 3. 



13. LANDSTEINER, Centralblatt Bacteriologie, 1899, Vol. XXV, page 546; 



Vol. XXVII, page 357. 



14. MALKOFF, Deutsche med. Wochenschr. 1900, page 229. 



15. MORGENROTH, Centralblatt Bacteriologie, Vol. XXVI, page 349; Vol. 



XXVII, page 721. 



16. NISSEN, Zeitschrift Hygiene, Vol. VI, page 487. 



17'. NUTTALL, Zeitschrift Hygiene, 1888, Vol. IV, page 353. 

 18. WASSERMANN, Zeitschrift Hygiene, Vol. XIX, page 408. 



