168 OMENTAL PLAGUE chap. 



the possibility of inoculation of the fed animal by pricks 

 of its skin or mucous membrane. As a matter of fact, in 

 no case was any such accident noticed — the animals either 

 succumbed with definite lesions of the ileum, denoting the 

 place of entrance of infection, or they remained alive. 



Guinea-pig No. 8 was found dead on May 16. 



The post-mortem examination showed a considerable 

 portion of the lower ileum swollen, deep purple in colour, 

 and hemorrhagic ; several Peyer's glands swollen and 

 necrotic ; the interior of this part of the ileum, as also of 

 the adjoining portions, appeared filled with sanguineous 

 matter, which in film specimens yielded B. pestis in 

 pure culture. The mesenteric glands were swollen and 

 hemorrhagic, showing also several whitish-grey necrotic 

 foci. The liver and spleen were crowded with grey 

 punctiform nodules. 



Cultures were made of the intestinal contents, of the 

 heart's blood, and of the spleen, As a result, in all cases 

 pure cultures of B. pestis were obtained, except as regards 

 cultures of the intestinal contents, which contained a small 

 number of B. coli in addition. 



Two mice were inoculated cutaneously with a trace of 

 the sanguineous intestinal contents of guinea-pig No. 8. 

 One of these mice was found dead on the third day, the 

 other on the fourth day. Both showed all the appear- 

 ances of typical acute plague ; the spleen and heart's 

 blood were literally packed with B. pestis. 



Sections were made through the hardened intestine, 

 the mesenteric glands, the spleen, and the liver of the 

 above guinea-pig, No. 8, and the results were practically 

 the same as were described in regard of previous rats. In 

 the swollen Peyer's patches the blood-vessels were dis- 



