VIII 



AGGLUTINATION OF B. PESTIS 



219 



The subcutaneous administration, many times repeated, 

 of Haffkine's prophylactic had therefore no result in 

 producing agglutinin such as was demonstrable after 

 repeated injection of small doses of living culture. 



4. Guinea-pigs Nos. 7 and 8. — These, which were 

 half-grown, were injected intraperitoneally on the following 

 dates, and with the following results : — 



No. 



Date of 

 Injection. 



Method of 

 Injection. 



Material (and Amount) Injected. 



1st 



2nd 



3rd 



4th 



5th 



6th 



7th 



8th 



June 17 



» 27 

 July 11 



„ 18 



August 1 



„ 29 



September 17 



October 21 . 



Intraperitoneal 



5 cc. of Haffkine's prophylactic. 



" »l JJ JJ 



" JJ JJ JJ 



U JJ » JJ 



n 



u JJ JJ JJ 



" JJ JJ JJ 



10 „ 



10 „ 



